DNP (2, 4-Dinitrophenol)
DNP Synonyms: 2, 4-dinitrophenol, reagent grade
DNP CAS: 51-28-5
DNP EINECS: 200-087-7
DNP MF: C6H4N2O5
DNP MW: 184.11
DNP MP: 108-112 ° C
DNP Density: 1, 683 g/cm3
DNP Vapor density: 6.35 (vs air)
DNP Storage temp.: 2-8° C
DNP Water Solubility: 0.6 g/100 mL (18 º C)
DNP Appearance: Light yellow to yellow crystals. Soluble in ethanol, benzene, chloroform and ether, dissolved in lye, slightly soluble in cold water.
Usage: Weight loss drug.
2,4-Dinitrophenol (2,4-DNP, or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. It is a precursor to other chemicals and is biochemically active, inhibiting energy (ATP) production in cells with mitochondria and was once used as a diet aid. 2,4-Dinitrophenol is produced by hydrolysis of 2,4-dinitrochlorobenzene.
DNP by some bodybuilders and athletes to rapidly reduce body fat content. Although many people think that DNP is dangerous for the human body, which is itself an efficient action principle is still considered to be studied, in order to seek potential treatment of obesity drugs. At present, the research focuses on the human body naturally occurring uncoupling protein.
Commercial is used as an antiseptic and as a pesticide. It is a chemical intermediate in the production of sulfur dyes, wood preservatives, and some herbicides including dinoseb and dinoterb. It has also been used to make photographic developer and explosives.
DNP Dieting aid:
2,4-Dinitrophenol was used extensively in diet pills from 1933 to 1938 after Cutting and Tainter at Stanford University made their first report on the drugs ability to greatly increase metabolic rate.After only its first year on the market Tainter estimated that probably at least 100,000 persons had been treated with 2,4-Dinitrophenol in the United States, in addition to many others abroad. 2,4-Dinitrophenol acts as a protonophore, allowing protons to leak across the inner mitochondrial membrane and thus bypass ATP synthase. This makes ATP energy production less efficient. In effect, part of the energy that is normally produced from cellular respiration is wasted as heat. The inefficiency is proportional to the dose of 2,4-Dinitrophenol that is taken. As the dose increases and energy production is made more inefficient, metabolic rate increases (and more fat is burned) in order to compensate for the inefficiency and to meet energy demands. 2,4-Dinitrophenol is probably the best known agent for uncoupling oxidative phosphorylation. The production or "phosphorylation" of ATP by ATP synthase gets disconnected or "uncoupled" from oxidation.
Dosage of DNP Powders:
The recommend dosage is between 2-6mg/kg-bw per day for crystalline 2,4-Dinitrophenol and 4-10mg/kg-bw for powdered 2,4-Dinitrophenol .
A beginner should always start off at the low end to assess tolerance. Trying this for the first time 2 weeks before a competition can be disastrous. A 220lb man is 100kg exactly. This means that if he is a first time user of crystalline 2,4-Dinitrophenol then he should take 200mg per day. I suggest staying with this dose for at least 3 days to keep it safe, then slowly increase the dosage. 400mg/day can be used, but never take it all at once. Always split up the doses as far as possible, so for 400mg/day that would mean taking 1 200mg capsule every 12 hours.
Only on rare occasions should someone attempt 600mg/day with the crystalline capsules unless its used by a very experi- enced user and all the vital signs are closely monitored. Cycle length depends largely on the individual. At first it was thought that a 2,4-Dinitrophenol cycle should be limit- ed to 10 days at the most because the thyroids shuts down and t4 to t3 conversion in the liver becomes nil, however, this is not the case. 10 days is a very arbitrary number.
A person taking 200mg/day would have almost completely normal thyroid function at day 10 whereas if s/he took 600mg/day, t3 would be non existent after 3 days. While the t3 hormone plays a very large role in determining fat loss, it should not be a big concern while on 2,4-Dinitrophenol because the fat burning capabilities of 2,4-Dinitrophenol will more than compensate for the suppressed t3 levels. An advantage to suppressed t3 levels is that the body will burn much less muscle while still burning fat on 2,4-Dinitrophenol . Normal t3 and thyroid function is restored within a week of stopping 2,4-Dinitrophenol .
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